Positive Predictive Value refers to the proportion of epidemiological units (e.g. animal, holding, herd) classified as diseased or infected by the surveillance system which are actually diseased or infected. It partly depends on the sensitivity and specificity of the surveillance system, but is also influenced by the disease prevalence in the target population.
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 Surveillance design step
 Advice for improvement of POSITIVE PREDICTIVE VALUE
1
 Surveillance system
1.1
 Hazard
1.2
 Surv. Objective
1.3
 Geographical area covered
1.4
 Susceptible species
1.5
 Risk characteristics
2
 Components overview
3
 Target population
3.1
 Target species
3.2
 Target sector
3.3
 Sectors missed
3.4
 Geographical area covered
3.5
 Target criteria
3.6
 Percentage covered
4
 Disease suspicion
4.1
 Definition
4.2
 Obligations
4.3
 Notification procedures
4.4
 Actions upon suspicions
4.5
 Actions upon confirmation
5
 Enhancements
6
 Testing protocol
 Consider choosing a test with higher analytical specificity to increase PPV.
6.1
 Type of test to be carried out
6.2
 Type of sample to be collected
 Choose a sample type that results in a low number of false positives.
6.3
 Pooling
 Pooling will decrease the PPV when inference is made at animal level, but it will increase it in case the inference is made at herd level.
6.4
 Screening/first test
 Consider choosing a test with higher analytical specificity to increase PPV. Ensure adequate quality assurance in the laboratory to avoid for example cross-contamination.
6.5
 Confirmatory/ second test
 Aim for a highly specific test. Also consider factors affecting diagnostic specificity such as training of field and laboratory staff, quality assurance in the field and in laboratories to avoid cross-contamination and the use of negative controls.
6.6
 Further details
7
 Study design
7.1
 Point of sample collection
7.2
 Selection of units
7.3
 Target unit
7.4
 Sampling unit
7.5
 Sampling design
7.6
 Number of units in the target population
7.7
 Sensitivity of the testing protocol
7.8
 Specificity of the testing protocol
8
 Sampling strategy
8.1
 Sampling at the primary sampling unit (PSU) level:
8.2
 Sampling at the secondary sampling unit (SSU) level:
8.3
 Selection criteria WITHIN the population
8.4
 Risk-based allocation
8.5
 Sample size calculation
8.6
 Sample allocation at the primary level
8.7
 Sample allocation at the Secondary level
8.8
 Sample collection timeline
9
 Data Generation/ Sampling collection process
9.1
 WHO will collect the samples?
9.2
 HOW will samples be collected?
9.3
 WHEN/HOW OFTEN will samples be collected?
9.4
 Training
9.5
 Follow-up
10
 Transfer means
10.1
 HOW will samples be transferred?
10.2
 WHEN/HOW OFTEN will samples be collected?
10.3
 Training
11
 Data Translation/ sample analyses process
11.1
 WHO will perform the analyses?
11.2
 HOW will samples be analysed
11.3
 WHEN/HOW OFTEN will samples be collected?
11.4
 Expected LOAD
11.5
 Training
11.6
 Follow-up
12
 Epidemiological analyses
12.1
 Are there any epidemiological DATA that need to be collected?
12.2
 WHO will perform the analyses?
12.3
 HOW will epidemiological analyses be performed?
12.4
 WHEN/HOW OFTEN?
12.5
 Training
12.6
 Data management needs
12.7
 Software needs
13
 Dissemination of results
13.1
 WHO will disseminate the results?
13.2
 WHO is the TARGET of dissemination?
13.3
 HOW will results be disseminated?
13.4
 WHEN/HOW OFTEN?
14
 Surveillance review
14.1
 Who
14.2
 When
14.3
 How often













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  • positive-predictive-value-ppv.txt
  • Last modified: 2018/07/31 18:11
  • by thorsten